MIVO CHIPS
SKIN-on-CHIP
A novel Skin-on-Chip Model for permeation and absorption studies
By mimicking the structure and function of the skin in a controlled and dynamic environment, our skin-on-chip model provides a powerful tool for studying the skin’s response to various stimuli, including drugs, toxins, and environmental factors.
This Skin-on-Chip model provides a more realistic and physiologically relevant environment that better mimics the in vivo conditions for studying the effect of different cosmetic and pharmaceutical products on the skin and developing more accurate and personalized treatments for various skin diseases.
Its innovative configuration is designed to comply with OECD 428 for in vitro skin absorption testing and can also be adapted for cosmetic and medical device applications.
Tissue Models Options
SKIN-ON-CHIP
Biomimetic membranes
2D cells monolayers
3D Reconstructed tissues
Biopsies
APPLICATIONS
Replicate the structure and function of the skin in a controlled and dynamic environment
Drug Discovery
Test the efficacy, toxicity and phamacokinetics of new formulations for topic applications.
Wound healing
Study the mechanisms of wound healing and immune involvement in the diffusive chamber included in our Skin-on-Chip Model.
Irritation tests
Study the effects of various toxins, pollutants, and other environmental stressors on skin health
Drug Delivery
Study the efficacy of different drug delivery systems for topical and transdermal drugs targeting immune cells or their interactions with the skin.
Toxicity & safety
Assess the toxicity and safety of various compounds and materials applied directly to the skin, including those that interact with the immune system.
Dermatology research
Investigate the effects of different patological conditions, such as psoriasis or atopic dermatitis, on skin health.
POSSIBLE OUTCOMES
Skin-on-Chip Model
A more realistic and physiologically relevant environment for more predictive readouts
Kinetic of permeation
Quantify the permeability of a set of drugs/molecules by analyzing the transport of these compounds over time. This approach provides valuable insights into the mechanism of molecular transport and can lead to the discovery of more effective formulations.
Cytotoxicity
Once testing compounds permeate and interact with the cells, evaluate cell viability using a live/dead assay. By detecting the optimal dose and potential cytotoxic effect, you can better understand the compounds’ impact on the cellular environment. This allows us to make informed decisions about formulations development and toxicity testing.
TEER MEASUREMENT
Trans Epithelial Electrical Resistance measurement is a valuable technique used to assess the integrity and stability of the cultured epithelial layers, monitoring cellular physiology and identifying disruptions in the barrier function.
Publications
Find a selection of publications for research purposes.
Workshops
Find a selection of posters for research purposes.
Webinars
Find a selection of protocols for research purposes.
CONTACT US
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