Skin Wound Healing Assay

Skin wound healing is a critical process involving tissue repair and regeneration, essential for restoring the physiological skin’s protective barrier. Effective wound healing treatments are vital in accelerating recovery and preventing complications, making the evaluation of new products in this area a key focus for both medical and cosmetic industries.

Purpose of the Test

This assay is performed to assess the efficacy of a testing
substance in healing skin wounds. This advanced MIVO based assay measures wound closure rates and cell proliferation using 2D/3D cellular models or ex vivo skin tissues.

The MIVO® Advantage: Accelerating Epithelial Repair Insights

The MIVO® skin on chip platform elevates skin wound healing assays by recreating a dynamic flow below the human skin, which properly resembles the nutrient diffusion into the skin tissue as in vivo. This cutting-edge technology allows for a more precise, predictive and quantitative evaluation of how treatments stimulate cell regeneration and accelerate tissue repair.

Our Unique Value Proposition

Predictive fluid dynamic Modeling: The MIVO® skin on chip platform recreates the dynamic flow conditions of human skin, offering the most predictive and reliable experimental conditions for evaluating wound healing treatments.
Deep, Mechanistic Insights: MIVO® goes beyond surface-level results, enabling a deeper understanding of cellular behavior during wound repair. It delivers precise data on wound closure, cell proliferation, and tissue barrier regeneration, unlocking critical insights into the true healing potential of treatments.
Faster R&D, Smarter Investments: MIVO® produces reliable, high-quality data, facilitating faster approvals for pharmaceutical, cosmetic, and medical device applications.

Skin Wound Healing Assay

In summary

SKIN wound healing assay tab
MIVO custom setup

READOUTS

  • Histology
  • Epithelial barrier integrity (TEER measurement)
  • Inflammation (i.e. IL6, IL8) optional
TEER measurement is performed before and after exposure to test drug, as indirect measurement of barrier integrity SKIN wound healing assay

TEER measurement is performed before and after exposure to test drug, as indirect measurement of barrier integrity.

Histological evaluation is performed to assess the closure of skin wound SKIN wound healing assay

Histological evaluation is performed to assess the closure of skin wound.

The ability of testing formulation to induce skin inflammation is assessed by quantification of pro-inflammatory cytokines (i.e. IL6, IL8) through ELISA assay SKIN wound healing assay

The ability of testing formulation to induce skin inflammation is assessed by quantification of pro-inflammatory cytokines (i.e. IL6, IL8) through ELISA assay.

Get a Quote

We are here for you

Whether you’re looking for a quote or want to connect with us, fill out the form below with your details, and we will be in touch shortly.

All fields are required, take your time.