Skin Toxicity Assay

It is a standard assay for evaluating the toxic biological response induced by test substances topically applied onto the skin. It provides a quantitative assessment of toxicity of medical devices, cosmetics, and drugs, ensuring product safety and regulatory compliance.

Purpose of the Test

This assay evaluates cell death induced by topical exposure of a compound at different doses, by meauring lactate dehydrogenase (LDH) release, a key marker of citotoxicity.

In addition to cytotoxicity, the test assesses barrier integrity variations, providing insights into changes in skin permeability induced by different doses of the compound.
When required, it can also include the analysis of inflammatory cytokines, offering a deeper understanding of biological response to teh tetsing compounds.

These evaluations are essential for regulatory safety assessments in product development and preclinical drug testing.

The MIVO^® Advantage: A Superior Predictive Model

The MIVO® Skin-on-Chip platform enhances conventional cytotoxicity testing by incorporating physiological fluid flow beneath the skin tissue, creating a biomimetic environment that better replicates human physiology. This dynamic system provides a more precise and reliable evaluation of compound effects, not only in terms of toxicity but also regarding skin barrier function and inflammatory responses. By offering a more comprehensive assessment, it improves the predictability of in vitro results, supporting the development of safer and more effective biomaterials, drugs, medical devices, and
cosmetics.

Our Unique Value Proposition

Humanized Cytotoxicity Model for Accurate Safety Assessment: The MIVO® platform redefines skin cytotoxicity testing by replicating the complex cellular interactions within human skin under physiological fluid-dynamic conditions. This cutting-edge model offers a more precise, relevant, and reliable prediction of cytotoxic effects, providing in-depth insights into how cosmetics, biomaterials, and medical devices impact skin health.

Dynamic Fluid Flow for Realistic Skin Conditions: MIVO® elevates traditional testing with its dynamic fluid flow system, simulating natural skin conditions with unparalleled accuracy. This advanced approach allows higher accuracy and predictability of cellular responses to testing compounds, offering a more comprehensive understanding of a substance’s impact on skin cells.

Comprehensive, Multicellular Testing for Product Safety: From cosmetics to medical devices, the MIVO® platform supports a broad spectrum of products, accommodating diverse chemical and physical properties.