Skin irritation OECD439

Skin irritation assay is essential in product development and regulatory compliance, to ensure the safety of substances coming into contact with human skin, being crucial for cosmetics, pharmaceuticals, and chemicals.

Purpose of the Test

The MIVO-based skin irritation assay uses the MIVO® skin-on-Chip platform to evaluate the safety of testing substances in a more reliable and human-relevant manner than traditional in vitro models. MIVO skin-on-Chip platform ®’s ability to faithfully recreate the complex dynamic fluid-flow structure of the human skin, along with its compatibility with Reconstructed Human Esophageal (RhE) tissue models, allows to mimic human skin structure
and function and predict skin responses to test substances.

The MIVO^® Advantage: A Superior Predictive Model

MIVO® organ-on-chip technology enhances traditional RhE models by introducing dynamic fluid flow, creating a more accurate simulation of physiological skin conditions. This dynamic interaction improves the prediction of local skin toxicity, providing a comprehensive, accurate solution for skin irritation testing.

Our Unique Value Proposition

Realistic, 3D, Humanized tissue Model: The MIVO® platform integrates a 3D RhE with dynamic fluid flow, simulating real-life skin conditions more effectively than static systems. This enhanced physiological accuracy allows for a more precise prediction of irritation potential and local skin toxicity.

Dynamic Fluid Flow for Better Precision, long term irritation tests and repeated doses treatments: Unlike static models, MIVO® incorporates dynamic fluid flow, ensuring that substances interact with the skin model in a way that mimics real human exposure (Pulsoni et al. 2022), leading to more accurate and predictive results. Moreover, the flow enables to significantly prolong the survival of Rhe in vitro, for testing long term irritation and repeated doses treatments.

Regulatory Compliance: MIVO® innovative configuration is fully aligned with OECD 439 for in vitro skin irritation testing. It provides a robust, reliable method for regulatory compliance in safety testing.

Versatile Applications: This system is highly adaptable, making it ideal not only for irritation and toxicity testing but also for cosmetic, pharmaceutical, and medical device product evaluations.

Throughput: the platform enables to carry out simultaneusly up to 12 independent experiments, supporting multiples doses evaluation of the testing compounds.