Gut Irritation & Tolerability

Gut irritation is a critical concern in the evaluation of substances that may come into contact with the gastrointestinal tract, including pharmaceuticals, food ingredients, contaminants, and environmental toxins. Assessing gut irritation helps predict adverse effects, ensure consumer safety, and comply with regulatory guidelines.

Purpose of the Test

Our gut irritation assay utilizes the MIVO® gut-on-chip technology to evaluate the safety of ingested substances. By replicating the dynamic fluid-flow conditions of the gastrointestinal tract, this advanced in vitro model provides a realistic assessment of compounds interactions with gut tissue. It enables precise irritation evaluation at different doses, offering valuable insights for compounds screening and optimization.

The MIVO^® Advantage: A Superior Predictive Model

Unlike traditional static models, MIVO® integrates dynamic fluid flow, better mimicking gut physiology. This innovation allows real-time monitoring of tissue responses, enhancing irritation predictions and ensuring a more reliable safety assessment for various compounds.

Our Unique Value Proposition

Realistic, 3D, Humanized Gut Model: The MIVO® platform integrates a 3D human intestinal model with dynamic fluid flow, replicating real physiological conditions more accurately than traditional in vitro systems. This enables precise evaluation of the irritation potential of substances on gut health.

Dynamic Fluid Flow for Better Precision, long term irritation tests and repeated doses treatments: MIVO®’s dynamic flow system ensures substances interact with gut tissue in a way that mirrors actual human ingestion. This offers more predictive and reliable results while enabling the assessment of long-term irritation effects and repeated exposure to compounds, such as contaminants or chronic drug usage.

Versatile Applications: Ideal for testing pharmaceuticals, food ingredients, contaminants (like microplastics), and other ingested substances, MIVO® offers broad adaptability for assessing the irritation potential of various compounds within the gastrointestinal system.