The new era of

3D Cell Culture

In 3D cell culture, cells are grown in a way that better mimics the in vivo environment, providing a more physiologically relevant system for studying cell behavior and interactions.

There are several methods for creating 3D cell cultures, including the use of hydrogels, scaffolds, and spheroids. Hydrogels are crosslinked polymers that can provide a supportive environment for cells to grow in 3D.
With its potential for more accurate and reliable results, 3D cell culture opened up exciting new opportunities for the development of novel therapies and treatments.

3D-flowGel

Super-fast, highly flexible, and reproducible, it’s a ready to use 3D cell culture hydrogel that closely resembles the extracellular matrix (ECM).

A new era of In Vitro Cell Culture with 3D-flowGel

Permissive to chemical functionalizations, stable over time, and mechanically tunable, 3D-flowGel allows optimization of the in vitro cell culture in a 3D fashion, encouraging long-term cell viability, selective migration, and protein secretion. Due to its chemical composition, 3D-flowGel supports an extensive spectrum of downstream analysis through an easy and fast cell recovery.
Moreover, 3D-flowGel recapitulates the in vivo tissue barrier conditions for more predictive diffusion of molecules, nanoparticles and drugs under testing.

Quick & Easy

Optically Transparent

Tunable Stiffness

Easy cells recovery

Easy functionalization

Animal free

MIVO® is the cutting-edge bioreactor that revolutionizes 2D and 3D cell culture techniques

In vitro 2D conventional cell cultures do not properly resemble the spatial complexity of the human tissue microenvironment. On the other hand, animal models, considered the current gold standard in many research applications, are time-consuming, remarkably laborious, expensive, and not fully translatable to human scenarios.
Unlike traditional 2D cell cultures, 3D cell cultures allow for a more realistic representation of how cells behave in the human body. With the ability to mimic the complex cellular microenvironment, 3D cell cultures have become an essential tool in drug discovery, toxicity testing, and tissue engineering.

MIVO®Platform is compatible with both traditional 2D and innovative 3D cell cultures (spheroids, bioprinted scaffolds, biomaterials, and biopsies) under fluid dynamic conditions as in vivo, enabling researchers to improve the reliability, robustness, and reproducibility of their tissue models in a more ethical approach, following the 3R.

Comparison with the most used commercially available animal derived matrixes

3D-flowGel
Competitors

Quick & Easy

does not require specific manipulations (e.g. ice)


Tunable Stiffness

to better resemble target tissue and affect cell behavior (mechanobiology)


Chemical functionalization

to introduce bioactive signals through chemical modification of the 3D matrix


Long-term stability

for months-long cellular experiments, even in physiological and dynamic fluid flow conditions.


Optical transparency

for easy monitoring of cell behavior


Inert

for cell culture with less off-target effects


Easy cells recovery

for further phenotype/molecular investigation


Affordable

for optimizing R&D costs


Animal-free

in line with 3R principles


Applications

3D cell migration

Invasion & infiltration

Drug diffusion

Cells differentiation

3D co-cultures

Controlled release

A wide spectrum of readouts

Phenotype Assessment

Phenotype Assessment

Vesicles internalization

Vesicles internalization

Immunofluorescence

mmunofluorescence

Histology

Histology

Viability Assessment

Viability Assessment

Molecular Analysis

Molecular Analysis

Analysis of secreted factors

Analysis of secreted factors

Molecule diffusion Analysis

Molecule diffusion Analysis

Publications

Find a selection of publications for research purposes.

Publications

Workshops

Find a selection of posters for research purposes.

Workshops

Webinars

Find a selection of protocols for research purposes.

Webinars
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