The new era of
3D Cell Culture
In 3D cell culture, cells are grown in a way that better mimics the in vivo environment, providing a more physiologically relevant system for studying cell behavior and interactions.
There are several methods for creating 3D cell cultures, including the use of hydrogels, scaffolds, and spheroids. Hydrogels are crosslinked polymers that can provide a supportive environment for cells to grow in 3D.
With its potential for more accurate and reliable results, 3D cell culture opened up exciting new opportunities for the development of novel therapies and treatments.
3D-flowGel
Super-fast, highly flexible, and reproducible, it’s a ready to use 3D cell culture hydrogel that closely resembles the extracellular matrix (ECM).
A new era of In Vitro Cell Culture with 3D-flowGel
Permissive to chemical functionalizations, stable over time, and mechanically tunable, 3D-flowGel allows optimization of the in vitro cell culture in a 3D fashion, encouraging long-term cell viability, selective migration, and protein secretion. Due to its chemical composition, 3D-flowGel supports an extensive spectrum of downstream analysis through an easy and fast cell recovery.
Moreover, 3D-flowGel recapitulates the in vivo tissue barrier conditions for more predictive diffusion of molecules, nanoparticles and drugs under testing.
Quick & Easy
Optically Transparent
Tunable Stiffness
Easy cells recovery
Easy functionalization
Animal free
MIVO® is the cutting-edge bioreactor that revolutionizes 2D and 3D cell culture techniques
In vitro 2D conventional cell cultures do not properly resemble the spatial complexity of the human tissue microenvironment. On the other hand, animal models, considered the current gold standard in many research applications, are time-consuming, remarkably laborious, expensive, and not fully translatable to human scenarios.
Unlike traditional 2D cell cultures, 3D cell cultures allow for a more realistic representation of how cells behave in the human body. With the ability to mimic the complex cellular microenvironment, 3D cell cultures have become an essential tool in drug discovery, toxicity testing, and tissue engineering.
MIVO®Platform is compatible with both traditional 2D and innovative 3D cell cultures (spheroids, bioprinted scaffolds, biomaterials, and biopsies) under fluid dynamic conditions as in vivo, enabling researchers to improve the reliability, robustness, and reproducibility of their tissue models in a more ethical approach, following the 3R.
Comparison with the most used commercially available animal derived matrixes
3D-flowGel
Competitors
Quick & Easy
does not require specific manipulations (e.g. ice)
Tunable Stiffness
to better resemble target tissue and affect cell behavior (mechanobiology)
Chemical functionalization
to introduce bioactive signals through chemical modification of the 3D matrix
Long-term stability
for months-long cellular experiments, even in physiological and dynamic fluid flow conditions.
Optical transparency
for easy monitoring of cell behavior
Inert
for cell culture with less off-target effects
Easy cells recovery
for further phenotype/molecular investigation
Affordable
for optimizing R&D costs
Animal-free
in line with 3R principles
Applications
3D cell migration
Invasion & infiltration
Drug diffusion
Cells differentiation
3D co-cultures
Controlled release
A wide spectrum of readouts
Phenotype Assessment
Vesicles internalization
Immunofluorescence
Histology
Viability Assessment
Molecular Analysis
Analysis of secreted factors
Molecule diffusion Analysis
Publications
Find a selection of publications for research purposes.
Workshops
Find a selection of posters for research purposes.
Webinars
Find a selection of protocols for research purposes.
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