Our Scientific Solutions

Skin On Chip

innovation radar category winner react4life

Skin On Chip: a novel model for permeation and absorption studies

By mimicking the structure and function of the skin in a controlled and dynamic environment, our skin on chip model provides a powerful tool for studying the skin’s response to various stimuli, including drugs, toxins, and environmental factors.

This Skin on Chip model provides a more realistic, completely humanized and physiologically relevant environment that better mimics the in vivo conditions for studying the effect of different cosmetic and pharmaceutical products on the skin and developing more accurate and personalized treatments for various skin diseases. Its innovative configuration is designed to comply with OECD 428 for in vitro skin absorption testing and can also be adapted for cosmetic and medical device applications.

Skin on Chip: Tissue Models Options

Biomimetic membranes

2D cells monolayers

3D Reconstructed tissues

Biopsies

Skin on Chip Applications

Claim Substantiation

To objectivate, validate and support product claims with scientific evidence through precise, reliable and reproducible testing on humanized models with skin on chip.

Efficacy Testing

To test the efficacy of active ingredients or formulations for cosmetics and medical devices, studying how they interact with human skin cells.

Mechanistic Insights

To gain a deep understanding of how bioactive molecules function in human body, studying their pathways and effects at a cellular level.

OECD 428

To perform transdermal absorption studies in accordance with OECD 428 guidelines, providing reliable and regulatory-standard data for safety assessments.

Pre-screening

To screen and select the most promising molecules before animal or human testing, offering valuable data for product development while saving time and costs with skin on chip.

Toxicity Testing

To identify potentially harmful effects on specific organs, including evaluating cytotoxicity from the dosage of natural ingredients, mitigating risks.

Example of Skin on Chip Assays

TRANSDERMAL TRANSPORT
SKIN AGING
SKIN INFLAMMATION
HYDRATION & ANTI-GRAVITY
SKIN-IMMUNE RESPONSE

BACTERIA CO-CULTURE
GUT-SKIN AXIS
HYPERPIGMENTATION
SKIN IRRITATION
WOUND HEALING

READOUTS

Skin on Chip

PERMEATION FRACTION

CYTOTOXICITY ASSESMENT

EFFICACY ASSAYS

Skin on chip supports not just a single type of quantitative measurement, but enables multiple parallel measurements at analytical, biological, and molecular levels.

TEER MEASUREMENTS

HYDRATION MARKERS VIA IMMUNOFLUORESCENCE

INFLAMMATION RESPONSE

Skin on Chip References

Pulsoni I et al, SLAS Technology, 2022 – Comparison Between Franz Diffusion Cell and MIVO, a novel Micro-physiological System for In Vitro Penetration Assay Using Different Skin Models. Read now >

Peñuela L et al., Exp Dermatol., 2018 – Atomic force microscopy for biomechanical and structural analysis of human dermis: A complementary tool for medical diagnosis and therapy monitoring. Read now >

EuroCosmetics 2028/26 – Testing the Future. Read now >

Cosmetic Technology 2018/21(2) – Anti-pollution: innovativo test in vitro per quantificare il particolato che entra nel nostro corpo. Read now >