Our Scientific Solutions
Organ on Chip
Organ on Chip: Biotech & Pharma Solutions
Unlock the potential of your research with our state-of-the-art organ on chip and innovative 3D fluid dynamic cell culture platform. Our approach provides highly predictive, reliable, and robust in vitro data, setting a new standard in the industry.
Pharmacokinetics and Pharmacodynamics (PK/PD) assays are crucial in the development of new molecules. Our advanced Organ on Chip MIVO® Technology, featuring single and multi-organ on chip systems, optimizes the final composition, dosage, and administration routes of your compounds. This ensures maximum effectiveness while minimizing adverse effects. Our service delivers unparalleled accuracy and reliability, offering faster and more precise data. This ensures that your project remains on track and meets deadlines, allowing you to focus on innovation and discovery.
Utilizing our MIVO OOC systems with different tissues or multi-organ combinations, our in vitro service generates novel insights into the human body’s effect on drugs, medical devices or testing compounds.
Organs on Chip Service Journey
Fast and Simple in Just 4 Steps
Design and Finalize Experiment Plan.
Quickly tailor the perfect experiment setup using our cutting-edge Organ on Chip MIVO® technology.
Preparation of Organ Models.
Ensures rapid preparation of organ models, ready for immediate use with high precision.
Compound Dosing and Sample Collection.
Benefit from precise compound dosing and seamless sample collection facilitated by our innovative Ongans on chip MIVO® systems.
Data Analysis and Reporting.
Receive detailed and reliable reports faster and easier.
Example of Organ on Chip Models
Select the organ you wish to study in a fully humanized in vitro environment. If you don’t see the model you need, reach out to our team.
Our R&D department is continually developing new models and may already be working on what organ on chip you require.
GUT
SKIN
Our advanced organ on chip gut models simulate the complex environment of the healthy and pathological human gastrointestinal tract to study molecule absorption, intestinal permeability, and bacterial interactions under realistic human physiological conditions.
Our advanced organ on chip skin model is designed to reproduce various levels of aging under healthy and pathological conditions for advanced studies of efficacy, barrier integrity, permeation, and more, providing comprehensive insights into how new treatments perform under realistic physiological conditions.
Example of Organ Models
Select the organ you wish to study in a fully humanized in vitro environment. If you don’t see the model you need, reach out to our team.
Our R&D department is continually developing new models and may already be working on what you require!
GUT
Our advanced organ on chip gut models simulate the complex environment of the healthy and pathological human gastrointestinal tract to study molecule absorption, intestinal permeability, and bacterial interactions under realistic human physiological conditions.
Model: Intestine
Application: Absorption
Readout: Fraction of permeated compound across gut tissue model.
Model: Oral Gastric Intestine
Application: PBPK
Readout: Different fractions of digested and permeated compound.
Model: Leaky Gut
Application: Mode of action/efficacy
Readout: Permeability, TEER.
Model: Gut-Immuno
Application: IBD
Readout: Istology, immunohistochemistry, TEER, permeability, cytokines profiles.
Model: Gut-Brain
Application: Serotonin release, GABA production.
Readout: Therapeutic effect.
Model: Gut-Liver
Application: ADME
Readout: Fraction of permeated and metabolized compound.
Model: Gut-Bacteria
Application: Mode of action/efficacy
Readout: Probiotic adhesion, TEER, short chain fatty acid quantification.
SKIN
Our advanced organ on chip skin model is designed to reproduce various levels of aging under healthy and pathological conditions for advanced studies of efficacy, barrier integrity, permeation, and more, providing comprehensive insights into how new treatments perform under realistic physiological conditions.
Model: Skin
Application: Hydration
Readout: Istology, immunohistochemistry, TEER.
Model: Skin-Tumor
Application: PK/PD
Readout: Skin permeation and anticancer efficacy.
Model: Skin
Application: Permeation
Readout: Fraction of permeated compound.
Model: Skin
Application: Inflammation
Readout: Pro-inflammatory cytokines profiles
Model: Skin
Application: Aging
Readout: Istology, immunohistochemistry, TEER, matrix protease quantification.
Model: Skin
Application: Wound Healing
Readout: Istology, immunohistochemistry, TEER.
Model: Intestine
Application: Absorption
Readout: Fraction of permeated compound across gut tissue model.
Model: Oral Gastric Intestine
Application: PBPK
Readout: Different fractions of digested and permeated compound.
Model: Leaky Gut
Application: Mode of action/efficacy
Readout: Permeability, TEER.
Model: Gut-Immuno
Application: IBD
Readout: Istology, immunohistochemistry, TEER, permeability, cytokines profiles.
Model: Gut-Brain
Application: Serotonin release, GABA production.
Readout: Therapeutic effect.
Model: Gut-Liver
Application: ADME
Readout: Fraction of permeated and metabolized compound.
Model: Gut-Bacteria
Application: Mode of action/efficacy
Readout: Probiotic adhesion, TEER, short chain fatty acid quantification.
Model: Skin
Application: Hydration
Readout: Istology, immunohistochemistry, TEER.
Model: Skin-Tumor
Application: PK/PD
Readout: Skin permeation and anticancer efficacy.
Model: Skin
Application: Permeation
Readout: Fraction of permeated compound.
Model: Skin
Application: Inflammation
Readout: Pro-inflammatory cytokines profiles
Model: Skin
Application: Aging
Readout: Istology, immunohistochemistry, TEER, matrix protease quantification.
Model: Skin
Application: Wound Healing
Readout: Istology, immunohistochemistry, TEER.
VAGINA
JOINT
By simulating the unique environment of vaginal tissue with organ on chip, we can accurately evaluate the effectiveness and safety of new treatments under physiological conditions, also reproducing different levels of aging and damage from viral or bacterial lesions.
With our advanced organ on chip joint models, it is possible to study the method of action and efficacy of various treatments, accurately assessing how therapies affect joint health and development under realistic physiological conditions.
VAGINA
By simulating the unique environment of vaginal tissue with organ on chip, we can accurately evaluate the effectiveness and safety of new treatments under physiological conditions, also reproducing different levels of aging and damage from viral or bacterial lesions.
Model: Gynecologic cancer
Application: PD, Efficacy
Readout: Dose response curve
Model: Vagina
Application: Hydration
Readout: Istology, immunohistochemistry, TEER.
JOINT
With our advanced organ on chip joint models, it is possible to study the method of action and efficacy of various treatments, accurately assessing how therapies affect joint health and development under realistic physiological conditions.
Model: Cancer Joint
Application: Mode Of Action/Efficacy
Readout: Occurrence of CTC metastatic progression
Model: Cartilage
Application: Inflammation
Readout: Pro-inflammatory cytokine profile
Model: Gynecologic cancer
Application: PD, Efficacy
Readout: Dose response curve
Model: Vagina
Application: Hydration
Readout: Istology, immunohistochemistry, TEER.
Model: Cancer Joint
Application: Mode Of Action/Efficacy
Readout: Occurrence of CTC metastatic progression
Model: Cartilage
Application: Inflammation
Readout: Pro-inflammatory cytokine profile
LUNG
LIVER
Our organ on chip lung models allow us to conduct comprehensive studies on safety, nanoparticle toxicity, and pollution effects. By mimicking the respiratory environment, we can evaluate how different substances interact with lung tissues, providing valuable insights into their potential health impacts.
By replicating the intricate liver architecture and its dynamic microenvironment, we can precisely assess drug metabolism and hepatotoxicity, helping to understand liver-specific responses and predicting potential side effects.
LUNG
Our organ on chip lung models allow us to conduct comprehensive studies on safety, nanoparticle toxicity, and pollution effects. By mimicking the respiratory environment, we can evaluate how different substances interact with lung tissues, providing valuable insights into their potential health impacts.
Model: Lung
Application: Safety
Readout: Cytotoxicity
Model: Lung
Application: Nanoparticle Toxicity/Pollution
Readout: Cytotoxicity
LIVER
By replicating the intricate liver architecture and its dynamic microenvironment, we can precisely assess drug metabolism and hepatotoxicity, helping to understand liver-specific responses and predicting potential side effects.
Model: Liver
Application: Metabolism
Readout: Fraction of metabolized compound.
Model: Liver
Application: Safety
Readout: Hepato-Toxicity
Model: Liver Tumor
Application: PK/PD
Readout: Liver Off-Target Toxicity (IC50) And Anticancer On-Target Efficacy
Model: Lung
Application: Safety
Readout: Cytotoxicity
Model: Lung
Application: Nanoparticle Toxicity/Pollution
Readout: Cytotoxicity
Model: Liver
Application: Metabolism
Readout: Fraction of metabolized compound.
Model: Liver
Application: Safety
Readout: Hepato-Toxicity
Model: Liver Tumor
Application: PK/PD
Readout: Liver Off-Target Toxicity (IC50) And Anticancer On-Target Efficacy
MIVO ORGAN ON CHIPS
ORGANS on CHIP
Explore our range of available Organ on Chip models & choose the one that best fits your research needs.
Choose your organ on chip 3D model of human organs to recapitulate human physiology and disease in vitro.
We offer a wide selection of Organ On Chip models with living tissues that accurately mimic the in vivo environment of human organs. These models are ideal for long-term experiments and chronic disease studies.
Select the organ you wish to study in a fully humanized in vitro environment. If you don’t see the model you need, reach out to our team. Our R&D department is continually developing new models and may already be working on what you require!
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