Probiotic Adhesion Assay

Exploring the interaction between probiotics and the gut mucosa is essential for selecting and screening the most promising probiotics for gut health before the clinical stage. Indeed, adhesion to the intestinal lining plays a crucial role in probiotic efficacy, as it enhances colonization, prolongs persistence in the gut, and promotes beneficial interactions with host cells, ultimately contributing to improved gut health and immune modulation.

Purpose of the Test

Our probiotic adhesion assay utilizes the MIVO® based gut-on-chip platform to simulate real-life conditions of the human gut. This assay assesses how probiotics or microbiota bacteria adhere to and interact with the intestinal mucosa, providing crucial insights into microbial colonization, gut health restoration, and the potential for long-term gut microbiome modulation.

The MIVO® Advantage: A New Era in Microbiome Research

MIVO® revolutionizes traditional models by introducing a double dynamic fluid flow, mimicking the natural movements within the gut lumen and in the circulatory circuit, providing a highly accurate simulation of human
gastrointestinal conditions. Unlike in vivo or clinical studies, MIVO® enables a robust, quantitative and reproducible analysis of bacterial adhesion to the
intestinal tissue, offering more reliable predictions about the behavior of probiotics and their potential therapeutic effects on the gut.

Driving Innovation and Setting New Standards

While regulatory frameworks for probiotic testing in gut health are still evolving, the MIVO® platform positions research at the forefront of this emerging field, paving the way for a new era in microbiome research. This innovative approach challenges the status quo, providing critical data that can drive further scientific exploration and potentially shape future regulatory standards in probiotic and microbiome-based therapies.

Our Unique Value Proposition

Realistic, 3D Humanized Gut Model with Mucus Layer: MIVO® gut on chip platform integrates a 3D human intestinal model with its mucus layer and proper barrier function that closely mimics the natural gut environment. This multilayered cellular model enables to test of probiotic adhesion and providing a more accurate simulation of the gut's protective barrier, which is essential for studying microbial interactions, bacterial colonization, and the effects of probiotics on gut health.

Dynamic Dual-Flow System for Physiological Relevance: The MIVO® gut-on-chip, with its innovative dynamic double-flow system, replicates both the gut lumen and circulatory flow. Unlike static models, where bacteria can suffocate the tissue due to lack of proper fluid flow, MIVO® gut-on-chip allows for healthy, functional co-cultures, providing more accurate and reliable results in probiotic adhesion and microbiota interactions.

Precise Evaluation of intestinal barrier function: The test provides a controlled environment to assess intestinal barrier function over time, offering clear insights into the impact of probiotic adhesion on barrier stability.