SKIN Permeation Assay OECD428

Understanding the permeability of substances through the skin is crucial for evaluating the safety and classification of topical products, pharmaceuticals, medical device and cosmetics. Skin permeation assays provide valuable insights into compounds absorption, delivering essential data for product development, repurposing, and regulatory approval.

Purpose of the Test

The skin permeation assay evaluates the fraction of test
substances absorbed using advanced in vitro or ex vivo skin models cultured within an innovative MIVO based diffusive chamber, which mimics in vivo conditions.

Regulatory Compliance

This assay adheres to the OECD Test Guideline 428, ensuring that products are tested and compliant with global safety standards.

The MIVO^® Advantage: A Superior Predictive Model

MIVO® skin on chip technology provides an advanced platform for evaluating skin permeability by closely replicating the physiological conditions of human skin. By introducing dynamic fluid flow, MIVO® enables more accurate measurements of substance absorption and skin penetration, offering reliable insights into product performance and safety.

Our Unique Value Proposition

High Flexibility: The MIVO® platform adopts a wide range of skin models, such as human or pig skin biopsies having different thicknesses, acellularized membranes mimicking the physisical structire of the skin, or cells layers. This flexibility enables to personalize the tests according to specific needs.

Dynamic Fluid Flow for Unmatched Accuracy: Unlike traditional models like the Franz cell, MIVO® introduces a constant and homogeneus dynamic fluid flow, replicating the natural movement of fluids below the skin. This physiological flow ensures more realistic skin permeation conditions, leading to significantly more accurate and reliable measurements of substance absorption and transport.

PDMS-Free Innovation: MIVO® platform is entirely PDMS-free, ensuring reliable, interference-free results that better reflect the true behavior of test substances.

Comprehensive Substance Testing: The MIVO® skin permeation assay is ideal for evaluating a wide range of substances—from small molecules to complex formulations—across industries like cosmetics, pharmaceuticals, and personal care products.